Prilosec is the brand name for omeprazole, a proton-pump inhibitor (PPI) that lowers stomach acid. People use it for heartburn, GERD, peptic ulcers, and as part of H. pylori treatment. It works better than antacids for healing because it turns down acid production at the source.
For over-the-counter use the usual dose is 20 mg once daily for up to 14 days. Prescription doses commonly run 20–40 mg once daily depending on the problem. Take it 30–60 minutes before your main meal — the drug needs your stomach to be active to work best. Don’t crush or chew delayed-release capsules; swallow them whole. If you’re treating H. pylori, Prilosec is given with specific antibiotics — follow the exact regimen your doctor prescribes.
If you’ve been on a PPI for a long time and want to stop, don’t quit cold turkey. Acid rebound can cause worse heartburn for a few weeks. Your clinician may suggest tapering the dose or switching to an H2 blocker for a short period while you step down.
Short-term side effects are usually mild: headache, nausea, diarrhea, or constipation. Long-term risks include lower magnesium, reduced B12 absorption, higher fracture risk if used for years, and a small increased risk of C. difficile infection. Rare but serious issues include acute interstitial nephritis — tell your doctor if you get unusual pain, blood in urine, or sudden swelling.
Prilosec affects liver enzymes (CYP2C19), so it can interfere with some drugs. The most talked-about interaction is with clopidogrel (a blood thinner) — omeprazole may blunt clopidogrel’s effect. It can also change levels of warfarin, certain antifungals, and some HIV meds. Always check with your prescriber or pharmacist when adding any new medicine.
When to see a doctor: get urgent help for vomiting blood, black stools, unintentional weight loss, difficulty swallowing, or severe abdominal pain. Also consult a clinician if symptoms persist after a 2-week OTC course — you may need tests or a different treatment.
Small lifestyle moves help a lot: avoid late-night meals, cut back on alcohol and smoking, lose weight if needed, and raise the head of your bed if reflux wakes you at night. Antacids can be used for breakthrough symptoms, but they don’t replace a full course of PPI when one is needed.
If you’re comparing PPIs, talk to your provider — pantoprazole and esomeprazole act similarly but may suit certain drug interactions or insurance plans better. Use Prilosec when it fits your condition and follow directions to get safe, effective relief.
Struggling with stomach acid or relentless heartburn? This long-read gives you the real story on Prilosec. Learn how it works, who should avoid it, rare and common side effects, and tips for safe use. Grab practical advice and facts you won't find on the bottle label. Get the info you need before popping your next omeprazole.