When you’re prescribed acitretin, a potent oral retinoid used primarily for severe psoriasis and other skin disorders. Also known as Soriatane, it works by slowing down skin cell growth—but that same power comes with serious risks. This isn’t a mild medication. It’s one of the strongest tools doctors have for stubborn skin conditions, but it’s not something you take lightly.
People taking acitretin often face dry skin, cracked lips, and peeling hands—common but manageable. But the bigger concerns? Liver damage, raised cholesterol, and vision problems. Studies show over 60% of users report dry eyes or night blindness, and some see their triglycerides spike dangerously high. Women of childbearing age must avoid pregnancy for at least three years after stopping acitretin—this drug can cause severe birth defects. Even small doses are risky if taken during pregnancy. That’s why doctors require strict birth control and monthly blood tests.
It also interacts with other drugs you might be taking. Mixing it with methotrexate raises liver toxicity risk. Using it with tetracycline antibiotics can cause dangerous pressure on the brain. And alcohol? It turns acitretin into a longer-lasting, more toxic version in your body. That’s why many doctors ban alcohol completely during treatment.
What you won’t find in the brochure are the quiet side effects—like mood changes, joint pain, or hair thinning. Some users report feeling unusually tired or depressed. Others notice their nails become brittle or their scalp gets flaky. These aren’t rare. They’re just not talked about enough.
If you’re considering acitretin, ask your doctor: What’s my liver function like? Do my cholesterol levels look okay? Have I had my eyes checked recently? Are there safer alternatives for my case? This drug isn’t a first-line fix. It’s a last-resort option for when other treatments fail—and even then, only if you’re willing to monitor your health closely.
Below, you’ll find real user experiences and doctor-backed advice on managing acitretin’s risks, spotting early warning signs, and knowing when to push back on your treatment plan. These aren’t just general warnings—they’re practical steps from people who’ve been through it.
Learn how to manage sleep disturbances caused by acitretin for psoriasis. Practical tips on moisturizing, sleep hygiene, and when to talk to your doctor for better rest without stopping treatment.